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KMID : 0895820110210030001
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Journal of Oriental Rehabilitation Medicine
2011 Volume.21 No. 3 p.1 ~ p.11
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Effects of Root of Scutellariae Radix against Inflammatory Response in the Spinal Cord Contusion Injury in Rats
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Yang Kee-Young
Choi Won-Ik
Shin Jung-Won
Park Seong-Ha
Kim Seong-Joon
Lee Jong-Soo
Sohn Nak-Won
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Abstract
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Objectives: This study was performed to evaluate the effects of root of Scutellariae Radix(SR) water extract against inflammatory response in the spinal cord injury(SCI).
Methods: SCI was induced by mechanical contusion following laminectomy of 10th thoracic vertebra in Sprague-Dawley rat. SR was orally given once a day for 7days after SCI. Myeloperoxidase(MPO) positive neutrophils infiltration was examined. Inducible nitric oxide synthase(iNOS) and tumor necrosis factor-α(TNF-α) expressions were observed with immunohistochemistry. Glial fibrillary acidic protein(GFAP) positive astrocytes were examined using immuno-fluorescence.
Results: 1. SR reduced MPO-positive neutrophils infiltration in peri-damage regions of the contusive SCI-induced rats. 2. SR reduced iNOS positive cells in the white matter of the contusive SCI-induced rats. 3. SR reduced TNF-α positive cells in the gray and white matter of the contusive SCI-induced rats. 4. SR reduced cell number and size of astrocytes in peri-damage regions of the contusive SCI-induced rats.
Conclusions :These results suggest that SR plays an inhibitory role against inflammatory response in the SCI.
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KEYWORD
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Spinal cord injury, Scutellariae Radix, Anti-inflammation, Neutrophil infiltration, iNOS, TNF-α
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